Type 1 Activity and Glucose (TAG-1) study
Research type
Research Study
Full title
A pilot study informing the feasibility and design of a continuous measures physical activity intervention in young adults with type 1 diabetes mellitus. Type 1 Activity and Glucose Study - TAG-1
IRAS ID
151156
Contact name
David Webb
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
0 years, 9 months, 31 days
Research summary
Regular exercise has many proven health benefits. However in people with insulin-deficit (type 1) diabetes exercise may cause large swings in blood glucose or (sugar) levels. This can be problematic and limit participation in important lifestyle pursuits. This study looks at how physical activity affects blood glucose levels in young adults with type 1 diabetes. It will combine information from simple physical activity and glucose measurement monitors in sixty men and women with type 1 diabetes. Wearing these devices at the same time over a period of seven days will enable us to look at the relationship between glucose levels and physical activity in great (minute by minute) detail. The seven day continuous monitoring period is sandwiched between two visits (Visit A-attachment and Visit B-detachment) with an extra Visit C for people opting into a sub study testing the accuracy of the glucose monitoring device immediately following a 30 minute bout of non-vigorous physical activity. A second sub study performed at Visits A and B will measure blood flow in the arm with an ultrasound machine. Whilst wearing the devices we will ask participants not to change their activity levels so that we can record “free-living”. It is also important that participants keep a food diary and a record of administered insulin during the seven day monitoring phase. During Visit B we will ask volunteers to undertake a treadmill test to see if fitness influences glucose levels after exercise. This test will require volunteers to become physically fatigued by progressively increasing the gradient of the tread mill. We hope information from this study will able us to design and test more effective and hopefully safer exercise programmes which will improve the lives of people with type 1 diabetes.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
14/EM/1194
Date of REC Opinion
19 Nov 2014
REC opinion
Further Information Favourable Opinion