TXIorDyE study
Research type
Research Study
Full title
A randomised parallel-group study of Texture and Colour Enhancement Imaging (TXI) versus dye chromoendoscopy for dysplasia detection in IBD surveillance.
IRAS ID
345257
Contact name
Jonathan Landy
Contact email
Sponsor organisation
London North West University Healthcare NHS Trust
Duration of Study in the UK
1 years, 3 months, 0 days
Research summary
Bowel cancer in people with inflammatory bowel disease (IBD) often starts from abnormal changes in the cells lining the bowel, known as dysplasia. International guidelines recommend undertaking regular camera tests of the bowel (colonoscopies) to check for precancerous changes in IBD patients. In the past, these precancerous changes were thought to be invisible, but with better camera imaging technology, most cases of these early changes can now be seen. However, it is still very difficult to find early precancerous changes as they often appear as small, flat, subtle lesions.
Important studies have shown that using a dye applied to the bowel lining during the camera test can help detect early changes better than standard colonoscopy. However, there are challenges to using dye, such as the extra preparation time needed, and the learning curve for the technique. Newer high-definition cameras (colonoscopes) have shown higher detection rates compared to the older standard cameras. Advances in imaging technology have also led to the creation of new techniques to better detect and identify abnormal tissues. One such technique is Texture and Colour Enhancement Imaging (TXI), which improves texture, brightness, and colour in high-definition cameras, making it easier to see small, subtle differences in tissue. This push-button technology is now available with the EVIS X1 system (Olympus) of colonoscopes which are used in regular clinical practice.
There are no randomised studies on how well TXI works for finding early precancerous changes during colonoscopy check-ups in IBD patients. We plan to conduct a randomised study comparing Texture and Colour Enhancement Imaging (TXI) with dye to see which is better for detecting precancerous changes in IBD patients.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
25/EM/0258
Date of REC Opinion
14 Nov 2025
REC opinion
Favourable Opinion