Tuberculosis Drug Levels in Diabetics
Research type
Research Study
Full title
Comparison of anti-tuberculous drug levels in diabetic and non-diabetic tuberculosis patients
IRAS ID
272420
Contact name
Jessica Barrett
Contact email
Sponsor organisation
London North West University Healthcare NHS trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
0 years, 9 months, 0 days
Research summary
This study compares blood levels of tuberculosis medications between diabetic patients and non-diabetic patients. There is some research that suggests these medications are at lower levels in diabetic patients with tuberculosis, and this could adversely affect the outcome of their infection. Diabetic patients are at higher risk of dying or having a severe episode of tuberculosis therefore it is important that their care is optimised as far as possible.
To answer the research question all participants in the study will have an extra blood sample drawn at the same time as their routine blood tests which are used to monitor their tuberculosis treatment. Some participants will have additional blood samples taken at different times to give a more accurate picture of the medication levels in their bloodstream. The study will be conducted in the tuberculosis clinics at London North West University Healthcare NHS Trust and will include a total of 48 adult patients, half of whom have diabetes, who have recently been diagnosed with tuberculosis.
Some other information about their routine medications, weight and height, and severity of diabetes will also be collected, to see if these affect the medication levels in the bloodstream as well.REC name
East of England - Cambridge East Research Ethics Committee
REC reference
20/EE/0020
Date of REC Opinion
13 Feb 2020
REC opinion
Further Information Favourable Opinion