Troponin testing in myositis
Research type
Research Study
Full title
Troponin testing in patients with idiopathic inflammatory myopathy and systemic sclerosis spectrum disorders: Biomarkers of myositis disease activity and primary cardiac disease.
IRAS ID
164986
Contact name
Hector Chinoy
Contact email
Sponsor organisation
The University of Manchester
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
A study to investigate the usefulness of a panel of blood tests in the management of patients with idiopathic inflammatory myopathy (IIM) or systemic sclerosis (SSc)-spectrum disorders.
The IIMs are disabling diseases characterised by muscle inflammation (myositis). SSc-spectrum disorders consist of complex diseases affecting the connective tissues, and can also include a component of myositis.
Myositis usually affects skeletal muscle (i.e. the muscles of the limbs) but can occasionally involve the heart muscle. Detecting heart muscle involvement can be difficult with the current tests available.
Blood levels of creatine kinase (CK) have traditionally been used to give an indication of the severity of disease affecting skeletal muscle. The usefulness of other muscle enzyme tests in this setting is uncertain. In addition, the ability of these blood tests to detect heart muscle disease is uncertain.
This study seeks to determine whether these other muscle enzyme tests might be useful to indicate the degree of skeletal muscle inflammation and give an indication of heart muscle involvement.
The blood tests used in this study consist of creatine kinase (CK), cardiac troponin T (cTnT), cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB). These are all muscle enzymes that can be released from inflamed muscle (skeletal muscle or heart muscle).
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
14/EM/1248
Date of REC Opinion
14 Nov 2014
REC opinion
Further Information Favourable Opinion