Trauma, Cognition, Transition and Outcome in UHR Psychosis
Research type
Research Study
Full title
The Effects of Traumatic Experiences on Neurocognitive Function and Illness Trajectory in Adults presenting at Ultra High Risk [UHR] of Psychosis: An Accelerated Cohort Study.
IRAS ID
234331
Contact name
Ciaran Mulholland
Contact email
Sponsor organisation
Northern Health & Social Care Trust
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
This study will examine the effects of trauma on neurocognition and illness trajectory [Transition to Psychosis & Diagnostic Outcomes] in people experiencing prodromal psychosis, also termed an 'At Risk'/'Ultra High
Risk' Mental State. Belonging to the clinical UHR group is associated with high levels of reported trauma, impairments in neuropsychological performance and alterations in the structure, function, connectivity and neurochemistry of the brain.
Primary Objective: The effect of traumatic experiences on neurocognitive functioning in the UHR group [n=60; 16-35 years] will be compared to effects observed in three comparator groups: those who have experienced a First Episode of Psychosis [n=60; 16-35 years], those with an established Major Psychotic Disorder [e.g. a diagnosis of schizophrenia; n=60; 16-35 years] and a convenience sample of controls [n=60; 16-35 years]. The PO will be achieved over two years: a one-year sampling period and through repeat testing during a one year follow-up period. Traumatic experiences, alcohol and substance use/abuse, depression and anxiety will be established using standard published self-rating questionnaires. To assess cognition, the Primary Outcome, the study will use automated CANTAB Connect Research tests that are sensitive to the development of schizophrenia and major affective disorders. These tests will be administered using an ipad.
Secondary Objective [SO]: to track and examine the impact of traumatic experiences and neurocognitive functioning on risk of transition to psychosis in UHR participants, and diagnostic outcomes in those who have transitioned to psychosis and experienced a First Episode of Psychosis, will be examined at one and two years following referral to the STEP service and/or admission for a First Episode of Psychosis. The Secondary Outcomes [Transition to Psychosis Status, Time to Transition and Diagnoses] will be established using participants casenotes.
Data analyses will be performed using a commercially available statistical package.REC name
HSC REC B
REC reference
17/NI/0172
Date of REC Opinion
12 Oct 2017
REC opinion
Further Information Favourable Opinion