Transdermal nanoparticle behaviour
Research type
Research Study
Full title
Nanoparticle behavior in human and artificial skin-muscle tissue
IRAS ID
117286
Contact name
George Saleh
Contact email
Sponsor organisation
Moorfields Eye Hospital NHS Foundation Trust
Research summary
Summary of Results
This project set out to develop nanoparticle (nano sized - which are very small) carriers to transport anaesthetic across eyelid skin as an alternative to needle delivery. Over the course of the study, we used eyelid skin that was routinely excised during surgery and used this to conduct the experiments. We developed and adapted various nano-carriers (very small drug delivery systems) and packaged commonly used anaesthetic in them, after which we conducted laboratory experiments to see what dose of anaesthetic delivery across the skin with each type was. The skin is a formidable barrier and does not allow much through, so to reach anywhere near the level of anaesthetic a needle (which bypasses the skin) can deliver is very challenging. The study showed several promising candidate delivery systems in the laboratory. Future work will focus on how this can be applied in the clinical setting.REC name
Wales REC 4
REC reference
13/WA/0066
Date of REC Opinion
28 Feb 2013
REC opinion
Favourable Opinion