Transcriptomic approaches to infection with Treponema pallidum
Research type
Research Study
Full title
Transcriptomic and next generation sequencing approaches to infection with Treponema pallidum
IRAS ID
226896
Contact name
Michael Marks
Contact email
Sponsor organisation
London School of Hygiene & Tropical Medicine
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 2 months, 30 days
Research summary
Syphilis is an important sexually transmitted infection. There has been an epidemic of syphilis amongst men who have sex with men in the United Kingdom in the last decade. Early infection with syphilis causes a genital ulcer followed, in the absence of treatment, by a generalised illness often accompanied by rash. Studies on the pathogenesis of syphilis have been limited because it is not possible to grow syphilis outside of the body. New approaches using molecular tests allow the immune response of the patient to infection to be measured directly from a swab of a genital ulcer or rash and/or a blood sample and also allow the whole genetic sequence of the bacteria to be obtained from a swab. In this study we will collect swabs from ulcers or rashes and a blood sample from patients with syphilis and measure both the response of the patient immune system and the genetic sequence of the bacteria. Patients will be enrolled at sexual health clinics in the UK. Patients will receive standard medical care including standard treatment for syphilis in line with national guidelines. Standard management already includes collection of a swab and a blood sample. For this study we collect an additional swab sample and an additional 5ml of blood for use in this research project. By better understanding host immune system responds to infection with syphilis we hope to gain better insights in to the pathogenesis of this important sexually transmitted disease.
REC name
North of Scotland Research Ethics Committee 1
REC reference
17/NS/0095
Date of REC Opinion
1 Sep 2017
REC opinion
Favourable Opinion