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TransATAC tissue core and DNA research bank

  • Research type

    Research Tissue Bank



  • Contact name

    Mitch Dowsett

  • Contact email

  • Research summary

    TransATAC tissue core and DNA research bank

  • REC name

    London - Bromley Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    25 Mar 2014

  • REC opinion

    Favourable Opinion

  • Data collection arrangements

    Approximately 2000 samples of breast tumour tissue have been collected from patients participating in a multinational randomised controlled trial of adjuvant hormonal therapy for postmenopausal women with early breast cancer (ATAC (now known as LATTE) Trial). According to the terms of their consent the patients in the ATAC (LATTE) trial have gifted their tissue for use in laboratory studies.
    We are seeking to maintain this collection as a tissue bank as defined by the Human Tissue Act, and investigate proteins and genetic markers that have been identified by current research as potentially having an important role in breast cancer.
    The tissue is stored as cores within tissue microarrays in the Academic Department of Biochemistry at the Royal Marsden NHS Foundation Trust.
    Laboratory test result data will be held in the Royal Marsden on computer, identified only by Trial Number, and will be sent periodically to the ATAC (LATTE) Trial Statistician to be linked with the clinical outcomes database maintained and stored at the Cancer Research UK Centre for Epidemiology, Wolfson Institute of Preventative Medicine, Queen Mary's School of Medicine and Dentistry, London.

  • Research programme

    The TransATAC study (REC ref no. 97/1/037) was undertaken to investigate the differential benefit for patients of one breast cancer treatment (anastrozole) over another (Tamoxifen) in patients participating in the ATAC (LATTE) trial (Trial No. 1033IL/0029). There have been many scientific publications relating to this sample set and it is well known in the scientific community. The tissue bank is a valuable resource for the investigation of biomarkers and will allow genetic analyses that may reveal differences in cancer cells that might impact on the response of a patient to treatment and on outcome. The ATAC (LATTE) Steering committee and Pathology Sub-committee will review and approve all research projects to be undertaken by the Royal Marsden and external collaborators. Approval will be based on the merit of the application only. Approved projects will have confirmed research proposals guiding the policy of technical work, transfer of any tissue and/or data and statistical analysis of the data. The research is likely to be both basic and translational, for example applying molecular biological techniques to investigate the effects of differences in RNA, DNA and proteins on response to, or side effects from, endocrine therapy in breast cancer patients.

  • RTBTitle

    TransATAC tissue core and DNA research bank

  • Establishment organisation

    The Royal Marsden NHS Foundation Trust

  • Establishment organisation address

    Academic Department of Biochemistry

    4th floor, Wallace wing

    Fulham Road, London

    SW3 6JJ