TOTEM Study.
Research type
Research Study
Full title
TOTEM: Total Body PET - Exploring new iMaging protocols for clinical research
IRAS ID
339077
Contact name
Gary Cook
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
5 years, 7 months, 19 days
Research summary
The introduction of Total Body Positron Emission Tomography (TBP) represents a major step change in positron emission tomography (PET) technology, with simultaneous acquisition of PET scan data over most of the body in one scan rather than in several steps.
This allows faster scans and at a lower radiation dose with the potential to extend research capabilities.
As there is only very limited experience worldwide of implementing TBP (and only one as yet in the UK), there is not yet any evidence-based agreement on optimal methods for acquiring and analysing the scans.
The primary objective of the TOTEM study is to optimise new imaging protocol acquisition methods for TBP from data acquired in patients undergoing clinical PET scans using clinical tracers.
Secondary objectives will be (i) to optimise scan data analysis methods, and (ii) to use novel analysis methods including machine learning.
Our overall aims will be to minimise radiation dose, scan time and analysis time.REC name
London - Chelsea Research Ethics Committee
REC reference
24/LO/0878
Date of REC Opinion
15 Jan 2025
REC opinion
Further Information Favourable Opinion