TORPIS
Research type
Research Study
Full title
The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
IRAS ID
304910
Contact name
David Newby
Contact email
Sponsor organisation
University of Edinburgh
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
BHF Fellowship Grant, FS/CRTF/21/24129
Duration of Study in the UK
2 years, 5 months, 6 days
Research summary
Strokes are a major cause of disability and death. The consequences of stroke for the patient and their family can be devastating. The commonest type of stroke occurs when a blood clot breaks off within the body and it lodges in the brain. Very often, it is unclear if a blood clot caused the stroke and where it came from. This has limited how we treat and prevent strokes. We have developed a new technique that can see blood clots in the body by using a sophisticated scanning technique. This uses trace amounts of radiation that is incorporated into a smart probe that only sticks to blood clots. For the first time, we will be able to see which types of stroke are caused by blood clots and where these clots have originated from. This could markedly change how we manage and treat patients with stroke with implications for the patient’s treatment and the prevention of further strokes occurring.
Patients who have had a stroke will be recruited from the Royal Infirmary of Edinburgh and undergo the new scan. Patients will also undergo a clinical examination, and have a blood sample, ECG and ultrasound scan of the heart taken. Some patients will also need to wear a heart monitor for up to 7 days and a MRI scan of their head. This will all happen within 3 weeks of enrolment in the study. Subsequently, participants will be asked to completed a questionnaire about their health at 6-12 months and we will also review their electronic health records at this time. Following this, there will be no more research procedures for the participant. The length of the study will be between 6 and 12 months.
REC name
West of Scotland REC 5
REC reference
21/WS/0165
Date of REC Opinion
26 Jan 2022
REC opinion
Further Information Favourable Opinion