TONiC Phase 6 (samples only)
Research type
Research Study
Full title
Trajectories of Outcome in Neurological Conditions
IRAS ID
268738
Contact name
Carolyn A Young
Contact email
Sponsor organisation
The Walton Centre NHS Foundation Trust
Duration of Study in the UK
10 years, 0 months, 1 days
Research summary
1) Consent patients to phase 6 which involves participants having samples taken. Therefore a new phase 6 PIS and consent form has been introduced. Linking our current TONiC information to the information obtained from blood,
saliva or other biosamples would be a very powerful way to understand some of the more fundamental questions in neurological conditions such as what are the environmental, biological and genetic factors that determine disease
severity.2) Consent control subjects – PIS and consent In order to understand the relevance of the blood or stool/urine results, we need to compare people with the condition and those who are similar except that they do not have the
condition.3) Addition of environmental questionnaires Environmental factors including air pollution levels and sunlight exposure can be obtained by knowing the location (postcode if possible) of where the participants spend most of their time (live
and work).4) Addition of 3-day food diary. To analyse the microbiome, we would need a sample of faeces, and information on diet and medication obtained by a questionnaire
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
19/NW/0536
Date of REC Opinion
2 Dec 2019
REC opinion
Further Information Favourable Opinion