Tomographic ultrasound angiographic assessment in PAD - V1
Research type
Research Study
Full title
Contrast enhanced tomographic (3D) ultrasound assessment of the crural arteries and plantar arch in peripheral arterial disease.
IRAS ID
181651
Contact name
Steven K Rogers
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
2 years, 4 months, 1 days
Research summary
Summary of Research
Peripheral arterial disease (PAD) describes the build-up of atherosclerotic plaque within the arteries of the legs which, when it becomes flow-limiting, can cause a range of symptoms from intermittent claudication through to critical limb ischaemia. In severe cases, this can require catheter-based revascularisation using angioplasty or stenting, or arterial bypass surgery. The first line tool in the diagnosis of PAD is Duplex ultrasound, however this has limitations. To aid surgical planning surgeons still rely on alternative imaging, such as CT and MR angiogrpahy scans, which pose a risk to the patient. Tomographic ultrasound is a novel imaging modality that negates the risks of alternative imaging and may play a role in PAD treatment planning. The risks of tomographic ultrasound are also negligible compared to other types of scans.Summary of Results
: Clear imaging of below knee and foot arteries is essential to plan surgery when arteries become blocked. Contrast enhanced tomographic 3D ultrasound (CEtUS) is novel and entirely safe type of scan. In the present study we compared this new type of scan with CT and MRI scanning to calculate it’s accuracy.
In the same week as computed tomography, magnetic resonance or catheter angiography, CEtUS was performed. Images were compared using a modified Society of Vascular Surgery (SVS) runoff score.
We found that CEtUS is a novel imaging modality. Our data shows that two scientists came to the same diagnosis making the test reproducible. We also found strong agreement between CEtUS and CT or MRI scans which means it may play a role in clinical practice in the future.REC name
North West - Greater Manchester Central Research Ethics Committee
REC reference
15/NW/0663
Date of REC Opinion
7 Oct 2015
REC opinion
Further Information Favourable Opinion