To study clinical radiological and genetic predictors of outcome in MS
Research type
Research Study
Full title
Understanding the relationship between genotype and neurodegeneration in response to disease modifying treatments in multiple sclerosis: A pilot exploratory study employing high-dimensional inference of existing datasets.
IRAS ID
200980
Contact name
Olga Ciccarelli
Contact email
Sponsor organisation
University College London Hospital Trust
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
4 years, 9 months, 31 days
Research summary
We aim to explore MRI imaging as a biomarker of disease progression in Multiple sclerosis (MS) patients, and to ascertain how genetic variation contributes to clinical outcome, with the view to inform future clinical practice. This is a novel study that uses: (i) data from medical notes, including symptomatic and MS treatments, (ii) all health-related records, including MRI images acquired routinely for clinical proposes (iii) individual genetic profile and any other information obtained by NIHR BioResource. Since these data provide a larger number of variables compared to the number of patients studied, they are called high-dimensional data.
REC name
London - Queen Square Research Ethics Committee
REC reference
18/LO/1249
Date of REC Opinion
31 Aug 2018
REC opinion
Favourable Opinion