TIPTOP: Tolerance Induction to Pancreatic-Type One Diabetes Peptides
Research type
Research Study
Full title
Tolerance induction to pancreatic islet peptides in type 1 diabetes measured by the FAIM (Fluorescent dye-dilution and Activation Induced Marker) assay
IRAS ID
330847
Contact name
Parth Narendran
Contact email
Sponsor organisation
University of Birmingham
Clinicaltrials.gov Identifier
RG_23-142 , University study database
Duration of Study in the UK
1 years, 11 months, 28 days
Research summary
The aim of our work is to produce a cocktail of peptide epitopes based on dominant islet antigens for prevention and treatment of type 1 diabetes (T1D). Previously, we defined the rules governing the design of peptides (apitopes) for effective immunotherapy of autoimmune conditions. We have now developed an approach, the FAIM assay, that allows us to identify dominant T cells specific for islet antigens from the peripheral blood of T1D patients but also to isolate their T cell receptor (TCR) genes. We then use these patient derived TCRs to create reporter cell lines with which to design and test apitopes. Here, we will use this approach to identify dominant epitopes, design apitopes and, using the FAIM assay, test the ability of each individual T1D apitope to induce immunological tolerance. Ultimately, we will use the results of this study to prepare a cocktail of peptides ready for phase 1 safety studies in adults with T1D.
REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
24/EM/0090
Date of REC Opinion
19 Jun 2024
REC opinion
Further Information Favourable Opinion