Time variation of PRO scores in patients with chronic conditions
Research type
Research Study
Full title
Variation of patient-reported outcome scores across time in patients with chronic conditions: An interview study
IRAS ID
238523
Contact name
Antoinette Davey
Contact email
Sponsor organisation
University of Exeter
Duration of Study in the UK
1 years, 5 months, 1 days
Research summary
There is clear evidence in the chronic health literature showing that patients’ experience of their symptoms can vary over time, e.g. in a 24-hour cycle, different times of the week or year. Although there is research demonstrating that this variation of symptoms is experienced across different conditions, there is a lack of research focusing on how the variation affects patient-reported outcome scores. Patient-reported outcome measures, or PROMs assess health status or health-related quality of life from the patient’s perspective. The aim of the study is to explore in depth the time variation of patient-reported outcomes for individuals with multiple chronic conditions within and across different time intervals. By time variation we mean variation in patient repeated health status/scores. This is a longitudinal qualitative study spanning 9 months, interviewing up to 12 individuals at three different time-points. Individuals meeting the inclusion criteria (over 18 years, diagnosed with 2 or more of the following conditions: asthma, depression and/or osteoarthritis) will be asked to complete patient-reported outcome measurements using an online platform for the week prior to each of the three interviews. The completion of these measurements will vary at different times of the day, and different days of the week. The interviews will focus on their reports/scores and what influenced their answers during that week prior to the interview. In addition, the interviews will explore whether and how their symptoms vary over time and what external factors (socially determined) could impact on how they report their symptoms.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
18/SC/0179
Date of REC Opinion
22 Mar 2018
REC opinion
Favourable Opinion