TIGER study

• Research type

  Research Study

• Full title

  Distribution of lymph node metastases in esophageal carcinoma [TIGER]

• IRAS ID

  279600

• Contact name

  S.R. Markar

• Contact email

  s.markar@imperial.ac.uk

• Sponsor organisation

  Amsterdam UMC, AMR, prof. Dr. H.J. Bonjer

• Clinicaltrials.gov Identifier

  N/A, N/a

• Duration of Study in the UK

  7 years, 0 months, 0 days

• Research summary

  Rationale: Lymph node status is an important prognostic parameter in esophageal carcinoma and an independent predictor of survival. Distribution of metastatic lymph nodes may vary with tumor location, tumor histology, tumor invasion depth and neoadjuvant therapy. Surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy differs worldwide. Especially for adenocarcinoma the distribution of lymph node metastases has not yet been described in large series.
  Objective: Aim of the present study is to evaluate the distribution of lymph node metastases in esophageal carcinoma specimens following transthoracic esophagectomy with at least a 2-field lymphadenectomy.
  Study design: Observational cohort study.
  Study population: All patients with a resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with an at least 2-field lymphadenectomy is performed.
  Intervention (if applicable): Not applicable.
  Main study parameters/endpoints: The distribution of lymph node metastases in esophageal adeno- and squamous cell carcinoma.
  Nature and extent of the burden and risks associated

• REC name

  South Central - Hampshire A Research Ethics Committee

• REC reference

  20/SC/0293

• Date of REC Opinion

  7 Oct 2020

• REC opinion

  Further Information Favourable Opinion