TIDEs: Temporal Interference Drug Effects
Research type
Research Study
Full title
Investigating pharmacological modulation of Temporal Interference stimulation
IRAS ID
356557
Contact name
Amalia Ndoutoumou
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
1 years, 9 months, 29 days
Research summary
Neurological disorders are the leading cause of disability and illness in the world. Two relatively novel treatments demonstrate promising results for the treatment of various neurological conditions: Psychedelics and Non-Invasive Brain Stimulation (NIBS). It has been hypothesised that the clinical effects of both psychedelics and NIBS may be due to enhancement of neuroplasticity in the brain. Therefore, this mechanistic study in healthy volunteers aims to observe if psychedelics enhance the neurophysiological effects of NIBS. The main objectives of this study are to investigate the neuroplasticity and behavioural effects of combining N,N-Dimethyltryptamine or Ketamine with NIBS. To measure neuroplasticity changes we will employ neuroimaging techniques such as electroencechalography (EEG). To measure behavioural changes we will utilise a memory task. Psychometric questionnaires will be employed throughout the study. We are looking to recruit healthy participants (18-65 years old) who are mentally and physically healthy with no electroencephalography/NIBS exclusions. Recruitment and conduct of the study will occur at Imperial College London and Imperial College Healthcare Trust (ICHT). This study is funded by Imperial College London and the Rosetree trust.
REC name
London - Fulham Research Ethics Committee
REC reference
25/PR/1306
Date of REC Opinion
19 Nov 2025
REC opinion
Further Information Favourable Opinion