Thrombin generation in older adults with dementia
Research type
Research Study
Full title
Does an increase in thrombin generation (TG) explain the increase in the incidence of stroke, following the commencement of antipsychotic therapy in dementia patients
IRAS ID
142664
Contact name
Roopen Arya
Contact email
Sponsor organisation
The R&D Office
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
In recent years, published research suggests that patients who are diagnosed with dementia and concurrently prescribed anti-psychotic therapy, are at an increased risk of developing stroke. The exact reason for this is not known. The proposed study will investigate whether there is an increase in thrombin (a protein involved in blood clotting) generation, as assessed through the use of global coagulation assays, following the commencement of antipsychotic drug therapy in the dementia population.
REC name
London - Bromley Research Ethics Committee
REC reference
15/LO/0902
Date of REC Opinion
9 Jun 2015
REC opinion
Further Information Favourable Opinion