THRIVEN90
Research type
Research Study
Full title
Clinical Trial of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Oxygen in Women having Planned Caesarean Delivery
IRAS ID
240856
Contact name
Pervez Sultan
Contact email
Sponsor organisation
University College London Hospitals (UCLH)
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) is a technique for delivering large quantities of oxygen through a specialised apparatus into soft plastic tubing that sits in the nose. This results in warm, humid and fast-flowing oxygen blown directly into the lungs, which is comfortable to use in awake patients. This technique has been used by anaesthetists to fill up a patients lungs with oxygen before a general anaesthetic. This increases the length of time available to place a breathing tube and take over their breathing before the oxygen levels in the patients blood begins to fall.
An area this could be very useful is in obstetrics as pregnant women undergo changes in their body that results in them using up oxygen more quickly and make it more difficult for an anaesthetist to place a breathing tube. Pregnant women mostly get general anaesthetics in high-pressured emergency situations so we want to better define the optimal amount of THRIVE needed by an anaesthetist before starting a general anaesthetic.
We plan to recruit women at an NHS hospital undergoing elective C-section and test different amounts of THRIVE to determine what is the optimal amount needed to fill their lungs up to an oxygen level of more than 90%. Before surgery, participants will receive THRIVE for a set number of largest possible breaths. After the fixed number of breaths, the THRIVE apparatus will be removed and participants will then breath into a facemask to measure the level of oxygen in their lungs. They will undergo this procedure twice (mouth open, mouth closed) and will be monitored by an anaesthetist and midwife throughout. Afterwards, the C-section will proceed as planned.
REC name
London - Queen Square Research Ethics Committee
REC reference
18/LO/1148
Date of REC Opinion
31 Jul 2018
REC opinion
Further Information Favourable Opinion