THERAPIST Version 1.0
Research type
Research Study
Full title
Investigating relationships between IL-17, Th17 pathway activation and therapeutic response to TNF inhibition in RA patients.
IRAS ID
147240
Contact name
Amanda Foubister
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
2 years, 0 months, 3 days
Research summary
This study aims to treat eligible, biologic naïve RA subjects with anti-TNF therapies and take measurements of peripheral blood and synovial tissue to assess differences in the IL-17 and Th17 pathways between responders and non-responders. Clinical assessments, synovial bio-markers and ultrasound will be used as determinants of clinical response. The study may identify disease characteristics that determine which subjects may be more likely to respond to anti-TNF therapy, or those who may require either a different treatment option, or additional pathway inhibition in addition to TNF, in order to achieve clinical response.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
14/SC/1402
Date of REC Opinion
8 Dec 2014
REC opinion
Unfavourable Opinion