The use of octenilin® wound irrigation compared with Ringer’s solution
Research type
Research Study
Full title
Randomised controlled trial investigating the use of octenilin® wound irrigation in the management of chronic non-healing wounds.
IRAS ID
226817
Contact name
Jeanette Milne
Contact email
Sponsor organisation
University of Huddersfield
Clinicaltrials.gov Identifier
Huddersfield University , HUD - R00169-01
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
The objective of this clinical study is to investigate the efficacy of octenilin® wound irrigation compared with Ringer’s solution in the care of patients with wounds that are static (non progressing in the previous 4 weeks). The change in bacterial burden after 2 weeks of treatment will be used as the primary outcome measure. Secondary outcome measures will include changes in wound size and volume reduction and the development or absence of wound infection. The overall costs of both treatment regimens will also be compared.
Summary of Results:
Wound healing is a complex multifactorial process, chronic wounds fail to progress through all the stages associated with healing and get stuck in a pro-inflammatory state. This is often associated with covert (local) wound infection. This study sought to elicit if the application of a topical antimicrobial with surfactant properties was superior to saline in reducing local bacterial burden at the wound surface using topical wound swabbing to ascertain the level of bacteria in the wound at baseline, day 7 and day 14. The results show no statistical difference found in the groups between the control group and the octenillin group. However it does perform substantially better on some of the other outcomes, notably those in terms of wound volume and area reduction.REC name
HSC REC B
REC reference
17/NI/0139
Date of REC Opinion
2 Oct 2017
REC opinion
Further Information Favourable Opinion