The Use of MRE in the Diagnosis of Nodular Regenerative Hyperplasia
Research type
Research Study
Full title
The Use of Magnetic Resonance Imaging in the Diagnosis of Thiopurine-Induced Nodular Regenerative Hyperplasia
IRAS ID
165830
Contact name
Jeremy Sanderson
Contact email
Sponsor organisation
Guy's and St Thomas' Research and Development
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
Nodular regenerative hyperplasia (NRH) is a rare cause of liver disease but one which can occur with particular drugs such as thiopurines, a class of drugs which many patients with inflammatory bowel disease are on. There is currently no sensitive test, other than biopsy, to diagnose NRH. This is a pilot proof of concept study, on 10 volunatry patients, to assess whether MR Elastrography (MRE) can diagnose nodular regenerative hyperplasia (NRH) in patients who are already known to have the pathology histologically based on a biopsy performed within the last year. The ability of MRE to diagnose NRH will be compared to fibroscan which all participants will also undergo for the study.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
15/LO/1378
Date of REC Opinion
28 Sep 2015
REC opinion
Further Information Favourable Opinion