The SMARTER-CM Study

• Research type

  Research Study

• Full title

  Genetics, Imaging And Artificial Intelligence for Precision Care in Cardiomyopathy

• IRAS ID

  313058

• Contact name

  Becky Ward

• Contact email

  becky.ward@imperial.ac.uk

• Sponsor organisation

  Imperial College London

• Duration of Study in the UK

  4 years, 10 months, 31 days

• Research summary

  Cardiomyopathies are diseases of the heart muscle. Known genetic factors may account for some cardiomyopathy cases but there is still much to understand about the genetic and environmental causes and how the disease progresses. Finding new ways to diagnose and treat cardiomyopathies could improve the health and well-being of patients with these conditions.
  This study will collect data from individuals with cardiomyopathy or related heart muscle disease, or with a possible genetic predisposition to cardiomyopathy, and follow them over time to observe the progress of their heart and health.
  We will collect DNA, blood samples, and detailed clinical & lifestyle information at the start of the study, and data collected during routine healthcare visits over time.
  • learn what causes cardiomyopathy, and therefore how to treat it
  • understand why cardiomyopathy progresses differently in different people, so that we can improve our ability to recognise who will benefit from different treatments at different times

  We will collaborate with other centres internationally (the SHaRe consortium) to collect a large of group of participants with similar cardiomyopathies, providing us with the power to identify new pathways that cause disease and ways of predicting which participants are at risk of having more severe disease.

• REC name

  East of Scotland Research Ethics Service REC 2

• REC reference

  22/ES/0044

• Date of REC Opinion

  23 Jan 2023

• REC opinion

  Further Information Favourable Opinion