The role of the tumour microenvironment in thyroid cancer.
Research type
Research Study
Full title
Immune cell isolation, characterisation and interaction within the thyroid tumour microenvironment.
IRAS ID
169153
Contact name
Victoria L Green
Contact email
Sponsor organisation
Hull and East Yorkshire NHS R&D
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
This study aims to isolate immune cells from thyroid cancer tissue, allowing the type of T cells involved to be characterised as well as determining the phenotypes and percentage of different T cell subsets. From these tumour immune cells, individual populations will be isolated, expanded and their functional activity and chemical secretions assessed. As well as the immune cells, the epithelial and stromal cells from the tumour will be isolated and the secretome of these cells determined, in addition the effect of the secretome on the proliferation and function of the corresponding immune cells will be characterised. We further aim to investigate the relationship between these findings and patient responses to treatment, prognosis and recurrence.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
15/LO/1303
Date of REC Opinion
17 Jul 2015
REC opinion
Favourable Opinion