The role of sulphur biology in developmental dysplasia of the hip
Research type
Research Study
Full title
Sulfur biology in skeletal development: An explorative study in developmental dysplasia of the hip (DDH)
IRAS ID
229130
Contact name
Alexander Aarvold
Contact email
Sponsor organisation
University Hospital Southampton NHS Foundation Trust
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
Developmental dysplasia of the hip (DDH) is a shallow hip socket that can be present in children and predisposes to early onset arthritis. This causes pain and disability in young adulthood. Despite knowing how common it is and what are the main risk factors, the cause of it remains unknown. We are however steadily understanding more about the role of sulphur biology in the development of the human skeleton. It is highly likely that changes in sulphur processing play a role in causing DDH. By examining the sulphur content in urine of 100 recruited infants, the cause of DDH may become clearer. This could open the door to preventative treatment.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
17/YH/0442
Date of REC Opinion
21 Dec 2017
REC opinion
Further Information Favourable Opinion