The role of microvesicles in perioperative monitoring
Research type
Research Study
Full title
The role of microvesicles in perioperative monitoring
IRAS ID
300125
Contact name
George Hanna
Contact email
Sponsor organisation
Imperial College London
Clinicaltrials.gov Identifier
n/a, n/a
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
Oesophageal cancer is a common condition that is associated with poor survival. In the absence of a contraindication, surgery remains the mainstay of treatment for patients with localised oesophageal cancer. Surgery to remove oesophageal cancer (also called oesophagectomy) can lead to a major inflammatory response within the body that may lead to severe, sometimes life threatening, injury to the lungs. The is partly due to the requirement for one lung ventilation (with collapse of one lung) during surgery.
This research plans to study how microvesicles (small molecules released by cells) may influence the development of lung injury after oesophagectomy. We will recruit cancer patients who are undergoing surgical treatment for oesophageal cancer. We intend to collected samples of bronchoalveolar lavage fluid (BALF), plasma and urine from patients at the time of staging laparoscopy (baseline), on the day of oesophagectomy (start of surgery, before one lung ventilation, and end of surgery) and after surgery (day 1, 2,3 and 49). We will analyse microvesicles and inflammatory markers within these samples and correlate to clinical outcomes and parameters of lung injury. Patients undergoing major surgery for gastric cancer (that does not involve one lung ventilation) will serve as a control population.
It is hoped that by improving our understanding of the mechanisms that lead to severe lung injury in surgical patients, we may aid the development of future preventative and therapeutic strategies.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
21/PR/1554
Date of REC Opinion
14 Mar 2022
REC opinion
Further Information Favourable Opinion