The role of mast cell in Eosinophilic esophagitis

• Research type

  Research Study

• Full title

  COULD THE DISTRIBUTION OF MAST CELLS HELP TO DEFINE AND CATEGORISE THE NATURE OF THE EOSINOPHILIC ESOPHAGITIS AND EOSINOPHILIC COLITIS IN THE PAEDIATRIC POPULATION?

• IRAS ID

  204180

• Contact name

  Mike Thomson

• Contact email

  mike.thomson@sch.nhs.uk

• Sponsor organisation

  Sheffield Childrens NHS Foundation Trust

• Duration of Study in the UK

  2 years, 9 months, 31 days

• Research summary

  Primary Eosinophilic Gastrointestinal Disorders (EGID) is family of chronic inflammatory disorders comprising of Eosinophilic Esophagitis, Eosinophilic Gastroenteritis and Eosinophilic Colitis, where eosinophils infiltrate gut mucosa without any known cause. The clinical presentation depends on the part of gastrointestinal tract involved.

  Eosinophils are a type of white blood cells which are formed in bone marrow as response to increase production of cytokines like interleukins (IL3, IL5) and granulocyte macrophage colony stimulating factor (GM-CSF).
  The mast cells play an important role in stimulating the eosinophils, but their role is poorly understood in the pathogenesis of EGID.
  Though there is a consensus among international community about diagnosis and management of eosinophilic esophagitis, there is no clear cut definition or treatment guideline for eosinophilic colitis.

  Through this study we primarily aim to understand the role of mast cells in pathophysiology of eosinophilic esophagitis and colitis. We also aim to identify if mast cell tryptase has a role as a diagnostic tool for eosinophilic esophagitis, eosinophilic colitis and in differentiating GORD from EoE.We also aim to psiibly define eosinophilic colitis as there is no clear cut definition of this condition.

• REC name

  East of England - Cambridge Central Research Ethics Committee

• REC reference

  16/EE/0239

• Date of REC Opinion

  14 Jun 2016

• REC opinion

  Further Information Favourable Opinion