The role of immune cell subsets in cardiovascular disease
Research type
Research Study
Full title
The role of Immune cell subsets in the development of cardiovascular disease
IRAS ID
234563
Contact name
Ziad Mallat
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Duration of Study in the UK
2 years, 4 months, 1 days
Research summary
Atherosclerosis is a chronic inflammatory disease of the arterial wall responsible for most ischaemic cardiovascular diseases and stroke, the most frequent causes of death worldwide. It has become clear that the immune system cells play a critical role in disease and we wish to understand how these cells contribute to this inflammation. Our particular focus has been to utilise animal models to investigate which immune cell subsets play a role in atherosclerosis development and what factors drive them to contribute to disease. The purpose of this research using peripheral blood human cells is to utilise in vitro approaches to determine the relevance of these cells and pathways in humans.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
18/EE/0078
Date of REC Opinion
29 May 2018
REC opinion
Further Information Favourable Opinion