The role of biochemical markers in the pathogenesis of kidney failure
Research type
Research Study
Full title
Investigation of the role of trace metals, metabolites and proteins in the pathogenesis of kidney failure
IRAS ID
174596
Contact name
Lynn Webster
Contact email
Sponsor organisation
Manchester University NHS Foundation Trust
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Diabetes is a serious long term health problem. Uncontrolled glucose levels can lead to severe damage to the heart, eyes, kidneys and nervous system. Using animal models we have demonstrated that elevated copper levels may be causing these complications and that treatment with copper altering drugs can reverse some of the damage in the diabetic complications. In this study we aim to investigate whether copper levels and other biochemical markers are altered in humans with diabetes compared to the normal population and also to study copper and biochemical marker levels in patients with complications such as kidney disease not related to diabetes.
Patients with suspected kidney disease routinely have needle biopsies taken. We aim to collect tissue at the same time . We will also collect blood and urine to analyse the levels of trace metals metabolites and proteins. We also want to study the effects of transplantation (kidney and pancreas) on the levels of trace metals metabolites and proteins so biopsies blood and urine will also be collected from these patients. Some patients may also have a pancreas transplant in the event of the pancreas failing and being removed we will also look at trace metals, metabolites and proteins in the pancreas tissue.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
15/NW/0582
Date of REC Opinion
24 Sep 2015
REC opinion
Further Information Favourable Opinion