The RISK Study : Risk prediction for AKI in acute medical admissions
Research type
Research Study
Full title
Risk prediction for acute kidney Injury in acute medical admissionS in the uK : The RISK study. A prospective national, multi-centre study to collate data on all acute medical admissions in participating centres in order to develop a national risk assessment for AKI in secondary care.
IRAS ID
178464
Contact name
Lui G Forni
Contact email
Sponsor organisation
Royal Surrey County Hospital Foundation Trust
Duration of Study in the UK
0 years, 0 months, 8 days
Research summary
RISK is a prospective national, multi-centre study to collate data on all acute medical admissions in participating centres over a specified time period in order to develop a national risk assessment tool for the development of acute kidney injury (AKI) in secondary care. AKI is common in hospital in patients with a reported incidence of between 10 – 20% with much of the early data examining the outcome of critically ill patients but increasingly evidence has accumulated that suggests that all patients with AKI regardless of clinical setting have worse outcomes.This is reflected not only in terms of mortality risk but also an increase in the development of chronic kidney disease with its associated complications.
The problem with AKI is that it is defined by 2 parameters. Urine output (which outside specialist areas is rarely measured accurately) and change in serum creatinine a commonly employed measure of kidney function. Creatinine is an excellent tool for assessing and indeed directing treatment in chronic kidney disease. However in AKI any rise in creatinine may take 24 to 48 hours or more after the initial insult to rise. So as a test for acute problems it is not particularly good. The aim of this study is to investigate the relative contributions of patient admission physiology together with biochemical parameters, drug history and known co-morbidities to devise a practical, robust scoring system. It is hoped that this would be easily calculable and can rapidly identify patients at risk of developing AKI following admission. Therefore it would be a NEWS score for the kidney. Hopefully this score will flag up patients at risk of AKI and enable measures to be put in place to limit further AKI. We aim to collect data to enable score derivation plus a second validation cohort in 5 centres (approximately 10%).REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
16/YH/0244
Date of REC Opinion
2 Jun 2016
REC opinion
Favourable Opinion