The RISE test in heart failure
Research type
Research Study
Full title
A novel cardiopulmonary exercise test to estimate exercise intolerance in heart failure patients.
IRAS ID
182728
Contact name
Klaus Witte
Contact email
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
We want to find out if a new exercise protocol is associated with improved information about prognosis in patients with heart failure.
Peak exercise capacity (and peak oxygen consumption) are excellent measures of outcome and of change in the clinical condition. Hence we use either a treadmill or cycle based test to assess all patients with heart failure. Tests involve a gradually increasing workload until the patient can do no more. By combining electrocardiography with expired air analysis one can gain important insight into the function of the heart, lungs and muscles that are a powerful tool to predict prognosis and monitor changes.
In 2012 we introduced a new exercise protocol which consists of two phases. In addition to the standard ramp incremental test, where the workload becomes progressively harder until the patient can do no more, there is a brief rest period and then a brief step workload where the patient is asked to pedal as hard as they can for about 30 seconds.
Previous reports had suggested that this was a better way to determine peak exercise capacity. We have since identified that some patients can increase their peak oxygen consumption during the second phase and some cannot. We now want to find out whether the ability to push harder during the second phase is relevant in terms of patients' symptoms, and prognosis.
In order to do this we will look at the computers that run our exercise laboratory and search for all patients that have done this test. We will collate the data from the tests with data from the clinical notes and computerised records on outcomes. Only the clinical team will have access to the patient-identifiable data (they are all patients looked after by the heart failure unit),REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
15/YH/0283
Date of REC Opinion
11 Jun 2015
REC opinion
Favourable Opinion