The RETRAIN Trial Phase 2
Research type
Research Study
Full title
MonitoRing the Effect of Intermittent Pneumatic Compression and TRAnscutaneous functional electrIcal stimulation of the common peroneal Nerve using the geko® device on cerebral haemodynamics in patients with ischaemic strokes
IRAS ID
355812
Contact name
Kausik Chatterjee
Contact email
Sponsor organisation
Firstkind Ltd
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Ischaemic strokes, caused by a disruption in the brain's blood supply, are the second leading cause of death and disability in the United Kingdom. This single-center prospective randomised study aims to measure cerebral blood flow and oxygen delivery in patients who have recently suffered an ischaemic stroke and are using either the geko® neuromuscular electrostimulation device or an intermittent pneumatic compression (IPC) device as part of their routine clinical care.
The geko® device stimulates a nerve in the lower leg, inducing muscle contractions that enhance blood circulation. The IPC device applies controlled external pressure through compressed air and a pump, cyclically inflating and deflating chambers in a sleeve worn on the leg. This mimics the action of calf muscles to promote blood flow.
The primary objective of this study is to assess the effect of the geko® and IPC devices on cerebral blood flow in stroke patients, specifically during the hyperacute phase (within 36 hours) following an ischaemic stroke. Both devices will be used as part of standard care for VTE prevention. Cerebral blood flow will be measured using functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG).REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
25/NE/0090
Date of REC Opinion
19 May 2025
REC opinion
Favourable Opinion