The RESET for Remission Study
Research type
Research Study
Full title
Remission of diabetes and improved diastolic function by combining structured exercise with meal replacement and food reintroduction: THE RESET FOR REMISSION TRIAL
IRAS ID
286182
Contact name
Thomas Yates
Contact email
Sponsor organisation
University of Leicester
ISRCTN Number
ISRCTN15487120
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
Type 2 diabetes is becoming more common and adults are getting it earlier (aged between 18-40). This is worrying because these people are very likely to have heart, kidney and physical function problems at an early age. However, many of these effects have been shown to be reversible, either through weight loss caused by a low calorie diet or structured exercise. However, we don't know if combining the two leads to even greater improvements in young adults with type 2 diabetes.
The overall aim of the RESET for Remission programme is to investigate whether the combination of a structured exercise programme and a low calorie diet reverses diabetes and improves heart function, fitness, and other aspects of health when compared to standard care.
In total, 40 people (aged 18-40) will be randomly assigned to: usual standard care or a combination of an exercise programme and a low calorie diet for 24 weeks.
Standard care - This group will receive their normal diabetes care and will be provided with a leaflet outlining the benefits of diet and exercise. They will also be offered the low calorie diet at the end of the trial.
Low calorie diet and exercise - These participants receive packs that will replace all meals for two weeks and then all but one meal of the day for 10 weeks. After 12 weeks, participants will slowly return to their normal diet. Participants will also take part in supervised exercise three times each week (from weeks 3-12), before moving on to home based exercise (weeks 13-24).
We will look at how many people reverse their type 2 diabetes status. We will also look at changes in the heart, fitness levels, physical function, amount of fat and muscle and whether there is any change in mood or quality of life.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
21/EM/0026
Date of REC Opinion
22 Feb 2021
REC opinion
Favourable Opinion