The RE-ENERGIZE Study
Research type
Research Study
Full title
A RandomizEd trial of ENtERal Glutamine to minimIZE thermal injury
IRAS ID
213247
Contact name
Naiemen Moiemen
Contact email
Sponsor organisation
Queen's University at Kinston Ontario Canada
Clinicaltrials.gov Identifier
Duration of Study in the UK
5 years, 0 months, 28 days
Research summary
Burn injuries represent a public health problem worldwide, ranked fourth in all injuries and are among the leading cause of disability adjusted life years in low and middle-income countries. More than in any other injury, the inflammation and catabolism associated with severe burns can exacerbate nutrient deficiencies, thereby predisposing patients to impaired immune function and increased risk of developing infectious complications, organ dysfunction, and death. Consequently, over the last few decades numerous trials have evaluated the impact of different nutrition/nutrient strategies in severe burns patients. Glutamine is of particular interest in this regard as it appears vital for a number of key stress-response pathways in serious illness. The existing randomized trials of glutamine supplementation in burns patients have suggested a significant reduction in mortality, infection, and hospital length of stay. However, in other critically ill patient populations, there is a signal of increased mortality associated with glutamine administration. The purpose of the current proposal is to provide the rationale for a large clinical trial of supplemental enteral glutamine in 2700 severe burn injury patients.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
17/YH/0013
Date of REC Opinion
27 Feb 2017
REC opinion
Further Information Favourable Opinion