The Proline Fibrosis study
Research type
Research Study
Full title
PROline and FapI with Late gadolinium Enhancement in Myocardial Infarction PROFILE-MI “The Proline Fibrosis study”
IRAS ID
262478
Contact name
Marc Dweck
Contact email
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
We aim to examine whether 18F-Proline (radiotracer that binds in active collagen) can be used to quantify the fibrosis process (scarring) which is a process that affects various common conditions including heart attacks and aortic stenosis (narrowed valve). In particular, scarring appears to be the common final pathway of injury in the myocardium (heart muscle), underlying almost every heart condition.
Proline analogues have been used for decades to quantify scarring activity in vitro (in a test tube). Moreover, 18F -Proline tracers has already been used safely in humans demonstrating acceptable radiation doses.
In this study we are going to explore whether scarring activity is increased compared to healthy controls in the affected and healthy heart muscle following heart attack and to establish the time point of maximal scarring activity in these areas. We also aim to look at blood vessel scarring activity in aortic atherosclerosis (plaque disease) in patients with stable and unstable coronary (heart blood vessels) atherosclerosis (plaque disease).
REC name
South East Scotland REC 02
REC reference
20/SS/0022
Date of REC Opinion
5 Mar 2020
REC opinion
Further Information Favourable Opinion