The prevalence of OSA in patients with Diabetic Foot Ulceration
Research type
Research Study
Full title
A study to assess the prevalence of Obstructive Sleep Apnoea in patients with Diabetic Foot Ulceration
IRAS ID
276385
Contact name
Abd Tahrani
Contact email
Sponsor organisation
University of Birmingham
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
Diabetes-related foot ulceration (DFU) is a complication of diabetes. It occurs due to the damage in the blood vessels and the nerves in the foot. These ulcers can get infected and could lead to amputations. DFU worsen the patient's quality of life and is associated with increased mortality (5 year mortality of 40% for foot ulceration and 79% after lower limb amputation). DFU are very costly to the NHS (£972m - £1.13bn in 2014-15); approximately £1 in every £140 of NHS spend.
Despite national (National Institute for Health and Care Excellence) guidance recommending standards for the prevention, referral and optimal management of diabetes foot care across healthcare settings in England, the outcomes remain poor. Hence, there is a need to identify new treatment targets to improve outcomes in patients with diabetes.Obstructive sleep apnoea (OSA) is a very common condition in patients with diabetes. In OSA there is recurrent episodes of upper airways closure resulting in reduced or absent airflow during sleep, drop in oxygen levels, increase in heart rate and blood pressure and sleep disruption (sleepiness). Recent studies have shown links between OSA, inflammation, and nerve and blood vessels damage suggesting that OSA might contribute to DFU formation and might impair its healing.
This study aims to assess the prevalence of OSA within our patients who were newly referred with DFU to our centre. This will be achieved by undertaking a one-night home-based sleep test via a portable device that records airflow at the nose level, chest movements, and oxygen levels. In addition, we will examine the relationship between OSA and DFU severity.REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
21/NW/0261
Date of REC Opinion
6 Jan 2022
REC opinion
Further Information Favourable Opinion