The PREDICT Study
Research type
Research Study
Full title
PaRamEDIc assessment of laCTate in out of hospital cardiac arrest: measuring the association with survival to hospital
IRAS ID
271249
Contact name
Karl Charlton
Contact email
Sponsor organisation
North East Ambulance Service NHS Foundation Trust
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 7 months, 31 days
Research summary
\nA cardiac arrest occurs when the heart suddenly stops beating. NHS ambulance services attend approximately 30,000 such incidents annually to provide a treatment called resuscitation. Despite the efforts of the ambulance services, less than 1 in ten people survive.\nWhen a patients’ heart stops their body becomes deprived of oxygen, causing a rise in lactic acid (lactate). Lactate is used to identify patients at most risk of death in various emergency situations such as sepsis and in hospital cardiac arrest. To date no evidence exists to indicate if a lactate measured in the ambulance can identify those most at risk of death in out of hospital cardiac arrest.\n\nIt is possible to measure lactate accurately and rapidly in the ambulance using a small sample of blood and a small hand-held device. Results are available within seconds and may be valuable to the paramedic when making decisions regarding treatment.\n\nPatients will be included if they have suffered a cardiac arrest, are eligible for resuscitation as determined by current Resuscitation Council guidelines and aged 18>= years. They will be excluded if confirmed/suspected to be pregnant or if the cardiac arrest is as a result of a blunt/penetrating injury. We will only take 1 lactate measurement during the resuscitation attempt and all patients will continue to receive normal treatments. Standard care involves taking blood to measure blood glucose and the lactate measurement can be taken at the same time. \n\nWe will be able to follow up if patients survived to hospital, and to 30 days, remotely by routine data already collected by North East Ambulance Service. \nThe emergency situation precludes approaching the patient or their family/relatives, regarding study participation at enrolment. Patients will be enrolled without prior consent. We will seek full written consent from patients and/or their relatives who survive during the initial hospital stay.\n\n\n \n
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
19/YH/0363
Date of REC Opinion
5 Nov 2019
REC opinion
Further Information Favourable Opinion