The PRACTICE Trial
Research type
Research Study
Full title
Pulmonary Rehabilitation and ACTIvity after COPD Exacerbation - The PRACTICE Trial
IRAS ID
163228
Contact name
Jim Lithgow
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
ISRCTN Number
ISRCTN18634494
Clinicaltrials.gov Identifier
138144, URMS (University Research Management System)
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung condition that affects a person's ability to exercise and undertake normal activities due to breathlessness, poor physical fitness and muscle fatigue. Patients with COPD often experience flare ups known as "exacerbations" due to chest infections, which result in worsening of symptoms, more loss of function, and may require hospital treatment.
This pilot trial aims to assess the whether it is possible to undertake a larger study of exercise training in patients who have been admitted to hospital with COPD exacerbation. We aim to find out whether patients will be willing to participate and undertake exercise both during their time in hospital (a bedside bicycle based activity), and then immediately after they get home (a supervised exercise program undertaken during the first two weeks after discharge), to see if this will allow patients to recover more quickly. Both forms of exercise will be supervised by a Physiotherapist.
We will see whether participants are willing to undertake measurements including a walking test and wearing a motion detector at home. They will also be asked to complete questionnaires that ask about their activities and how their breathing problems are affecting their quality of life. Whilst in hospital a measurement of their muscle size will be done to see whether then exercise helps stops the muscles from wasting away.
We will check patient notes to assess whether there is any affect in preventing further chest infections or flare ups of COPD, or reduces the number of re-admissions to hospital occurring within 3 months of discharge.
This study will help us to understand if exercising earlier (then standard care) after hospital admission has any benefits over exercising later and will help us to decide if a large study looking more closely at this is required.
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
15/YH/0259
Date of REC Opinion
13 Aug 2015
REC opinion
Further Information Favourable Opinion