The PLEASE Study

• Research type

  Research Study

• Full title

  Physical Exercise and Mental Wellbeing Rehabilitation for Acute Stress-induced Takotsubo Cardiomyopathy: The PLEASE Study

• IRAS ID

  258176

• Contact name

  Dana Dawson

• Contact email

  dana.dawson@abdn.ac.uk

• Sponsor organisation

  University of Aberdeen

• ISRCTN Number

  NCT04425785

• Duration of Study in the UK

  2 years, 11 months, 31 days

• Research summary

  Acute takotsubo cardiomyopathy is characterised by sudden onset left ventricular dysfunction precipitated by major stress. We have shown that recovery is more protracted than previously appreciated, and is associated with persistent major morbidity and a long-term heart failure phenotype. In the absence of any effective therapeutic options, we propose a mechanistic three-arm pilot feasibility trial of early rehabilitation (standardised physical exercise training or cognitive behavioural therapy) versus current standard of care in patients who suffered a very recent episode of takotsubo cardiomyopathy.

• REC name

  North of Scotland Research Ethics Committee 2

• REC reference

  19/NS/0020

• Date of REC Opinion

  21 Feb 2019

• REC opinion

  Further Information Favourable Opinion