Influence of perfluorocarbon liquid (LIQUID) during pars plana vitrectomy on retinal vessel displacement in primary macula-involving rhegmatogenous retinal detachment
Research type
Research Study
Full title
Retinal displacement after pars plana vitrectomy for macula involving retinal detachment. A randomised prospective study evaluating the role of intraoperative perfluorocarbon liquids.
IRAS ID
327806
Contact name
Francesco Sabatino
Contact email
Sponsor organisation
Norfolk and Norwich University Hospitals NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Rhegmatogenous retinal detachment (RRD) is an acute, sight threatening condition, with an incidence of approximately 10 per 100,000 people. Surgical interventions for treating RRD include pars plana vitrectomy (PPV), which currently represents the main adopted surgical choice. Main outcomes of successful RRD surgery have mainly been represented by anatomical retinal reattachment and best-corrected visual acuity (BCVA). Despite successful surgery, patients with mac-off RRD often report postoperative visual complaints of distortion such as metamorphopsia and scotomas in their central visual field, with great variability.
Major advances in retinal imaging including wide-field optical coherence tomography (OCT) and fundus autofluorescence (FAF) allowed to investigate morphological changes after RRD surgery. The concept of retinal displacement - where the retina has reattached but the exact location has shifted, as evidenced by retinal vessel printing shown on post operative retinal imaging.
Postoperative retinal displacement has been observed to occur with different frequency in relationship to variables including postoperative tamponade, surgical technique, and intraoperative use of perfluorocarbon liquids (PFCL). We hope to formally study the impact of intraoperative use of PFCL, which is used as an aid during surgery to help flatten and position the retina, on retinal displacement. This will help us better understand the impact of this tool on outcomes both objectively through retinal imaging, and subjectively through visual outcomes including visual acuity and measures of distortion and other visual disturbances.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
24/EE/0139
Date of REC Opinion
22 Aug 2024
REC opinion
Further Information Favourable Opinion