The oscillation of crystalline and intraocular lenses
Research type
Research Study
Full title
The oscillation of crystalline and intraocular lenses: a feasibility study of the lens' movements in the eye
IRAS ID
262270
Contact name
Shahina Pardhan
Contact email
Sponsor organisation
Anglia Ruskin University
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
This study is to determine the amount of lens oscillations (wobbling) experienced in a normal population and those with certain conditions that predispose to severe lens oscillations.
The crystalline lens of the human eye helps to sharpen vision. There can be issues with the support/stability of the lens. This could be seen with the naked eye of an external observer or with the use of a slit lamp (eye microscope).Certain eye conditions can predispose to issues with lens stability. If patients have stability issues with their natural lens- this would be termed as “phakodenesis”. However, in patients who have had prior cataract surgery with implantation of an artificial lens (IOL)- this would be termed as “pseudophakodenesis”. Eye conditions such as pseudoexfoliation or Marfan-syndrome can lead to unstable lens support- this can be detected if there are advanced stability issues.
However, small instability in the eye’s would not be detected with present descriptive methods. The authors have designed a high-speed camera which is able to detect stability of the lens, especially during eye movements. The high-speed camera can detect variation in the change of light reflex from the lens and calculate the amount of lens instability/oscillation. The results (in normal eyes) of this high-speed camera have already been published in peer-reviewed journals. It is non-contact and measures lens movement. The test lasts less than 5 minutes.
Further research is required to assess the amount of lens oscillation (wobbling) in different eye populations- patients with previous cataract surgery (an artificial implant is used to replace the lens) or eye conditions (such as pseudo-exfoliation, Marfan syndrome). The amount of lens stability has a role in the planning of further intraocular surgery – especially cataract extraction- however, at present, there is no approved quantitative measurement for this.
REC name
East of England - Essex Research Ethics Committee
REC reference
20/EE/0240
Date of REC Opinion
14 Jan 2021
REC opinion
Further Information Favourable Opinion