The Nephrectomy Study Version 1.0

• Research type

  Research Study

• Full title

  To determine biological validity of multiparametric renal MRI using a model of nephrectomy-The Nephrectomy Study

• IRAS ID

  212976

• Contact name

  Simon Williams

• Contact email

  simon.williams3@nhs.net

• Sponsor organisation

  University Hospitals and Derby and Burton NHS Foundation Trust

• Duration of Study in the UK

  0 years, 10 months, 15 days

• Research summary

  Research Summary:
  Chronic kidney disease (CKD) causes considerable amounts of morbidity and indeed mortality. Similarly kidney cancers are usually asymptomatic and even for benign cancers patients have to undergo biopsy and nephrectomy (surgical removal of kidney).In this study we are planning to do MRI on the patients with kidney tumour and chronic kidney disease before their planned removal of the kidney.After the operation i-e surgical removal of the kidney,the tumour part will be resected as per pathology protocol and we will take tissue samples from the remaining part of kidney and perform MRI scans on the remaining part of kidney i-e without the tumour portion. In this way we are aiming to characterise the tumour and non-tumour part of the kidney radiologically through MRI and will correlate with histology slides. In the future it will help set up larger study to validate the MRI bio-markers for kidney tumour and chronic kidney disease to avoid invasive procedures like kidney biopsy . It is hoped this novel techniques will predict patients who are most at risk of progression of their CKD by having MRI scan. Having MRI scan on nephrectomy sample to study tumorous and non tumorous part of kidney along with histology help us characterise these patients to direct individual treatment.

  Summary of Results:
  This was a small research study to determine whether it would be feasible to use MRI to examine kidney tissue removed during surgery for kidney cancer. Two participants were recruited and we showed it was possible to scan the kidney tissue to generate high resolution images. This will inform future research studies using MRI

• REC name

  North East - Newcastle & North Tyneside 1 Research Ethics Committee

• REC reference

  19/NE/0061

• Date of REC Opinion

  14 Feb 2019

• REC opinion

  Favourable Opinion