The microbiome and transplantation
Research type
Research Study
Full title
The microbiome and transplantation
IRAS ID
233856
Contact name
Hussein Khambalia
Contact email
Sponsor organisation
MFT
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
In health, most of the body is covered in microorganisms. These include bacteria which have an important role in protecting us against infection. The number and types of organisms present are believed to change in response to the immunosuppressive drugs given after organ transplant. As a result, patients are at a significantly increased risk of infection. There have been no studies to our knowledge which have investigated the impact of immunotherapy after transplantation on the human microbiome. We plan to assess the types of organisms present in the mouth, urine, faeces, and skin scrapings from patients before and after kidney transplantation. Excess fluid from the bowel may also be taken in theatre for analysis. This study would allow us to find out how the commensal organisms are affected by immunosuppressive drugs, postulate how they can affect immunity and patient outcome, and consider the implications on future therapies.
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
19/NW/0100
Date of REC Opinion
27 Mar 2019
REC opinion
Further Information Favourable Opinion