The mechanism whereby an exogenous ketone drink lowers blood glucose

• Research type

  Research Study

• Full title

  The mechanism whereby an exogenous ketone drink lowers blood glucose

• IRAS ID

  242228

• Contact name

  Rhys Evans

• Contact email

  rhys.evans@dpag.ox.ac.uk

• Sponsor organisation

  TdeltaS Ltd

• Clinicaltrials.gov Identifier

  ISRCTN16169021, ISRCTN registry

• Duration of Study in the UK

  0 years, 4 months, 30 days

• Research summary

  How ketone bodies lower blood glucose?

  Why?
  In both animals and humans, that infusion of ketone bodies lowers blood glucose levels. However, there is controversy on the mechanism of action behind this phenomenon, and many different mechanisms have been proposed.

  How is it of relevance and importance to patients and public?
  Elucidating the mechanism behind this phenomenon could translate into a useful and novel treatment for diabetes.

  Who would be eligible?
  Healthy volunteers aged 18 - 70 years old.

  Where?
  The Department of Physiology, Anatomy and Genetics (DPAG) of the University of Oxford.

  How?
  You will be asked to fast for 24 hours and to consume a mix of the ∆G ketone drink and water. Afterwards, blood samples will be collected over two hours to measure levels of glucose, BOHB, L-Alanine and L-Glutamine. The estimated volume of collected blood is less than 30 ml (or about one fl oz).

• REC name

  East of England - Cambridge South Research Ethics Committee

• REC reference

  18/EE/0115

• Date of REC Opinion

  21 Jun 2018

• REC opinion

  Further Information Favourable Opinion