The LACE Study. Version 1
Research type
Research Study
Full title
Life after oesophageal cancer: The experience of the endoscopy patient - The LACE study
IRAS ID
224073
Contact name
Lisa Murray
Contact email
Sponsor organisation
University of Southampton
Duration of Study in the UK
0 years, 4 months, 16 days
Research summary
Life After Oesophageal Cancer: The Experience of the Endoscopy Patient \n\nOesophageal cancer (cancer of the gullet) is the 6th most common cause of cancer death in the UK, the most common type found in this country is oesophageal adenocarcinoma (OAC). New advances in endoscopic technology (the use of a camera which is passed over the mouth into the gullet) have resulted in earlier detection of abnormal changes in the lining of oesophagus and new ways to remove early cancers using an endoscope. \n\nThis approach offers many advantages to patients compared to surgery, as it has fewer complications and faster recovery times. However, patients undergoing endoscopic treatment often require ablation treatment which consists of having the surrounding area of the gullet burnt to reduce the chance of the cancer returning. They will also require regular endoscopic surveillance to check for cancer. \n\nAs the availability of specialist endoscopic procedures increases, it is essential that we understand what long-term effects this treatment may have on patients, to be able to identify new approaches to minimising these. The LACE study seeks to answer:\n\nWhat is the impact of the endoscopic pathway on patients with oesophageal adenocarcinoma?\n\n\n\nThe study was developed in recognition that the initial endoscopic treatment is one part of the patient’s treatment pathway and that for many patients, the effects of the treatment and the ongoing surveillance can have an impact well beyond this stage. The LACE study sets out to address the gaps in our current knowledge by using interviews to gather detailed information about the patient experience whereas previous studies have relied upon generic questionnaires to collect data relating to quality of life and the fear of cancer recurrence. These patients will be recruited from a specialist tertiary referral centre with expertise in the management of early oesophageal cancers. \n
REC name
London - Brent Research Ethics Committee
REC reference
17/LO/0820
Date of REC Opinion
9 May 2017
REC opinion
Favourable Opinion