The impact of the NHS LCD programme on patients with multimorbidity_V1
Research type
Research Study
Full title
Examining the impact of the NHS Low Calorie Diet programme on patients with multimorbidity (obesity, type 2 diabetes and osteoarthritis of the hip or knee)
IRAS ID
313211
Contact name
Louisa J Ells
Contact email
Sponsor organisation
Leeds Beckett University
Clinicaltrials.gov Identifier
49330, NIHR Clinical Research Network Portfolio reference: CPMS ID; researchregistry6614, Research registry reference:
Duration of Study in the UK
1 years, 1 months, 31 days
Research summary
This Study Within A Project (SWAP) is part of the review of NHS Low Calorie Diet (LCD) pilot which is already being conducted by the Chief Investigator and is funded by the NIHR HS&DR (ref: NIHR132075). The LCD review aims to provide an understanding of the effectiveness and acceptability of the LCD across broad and diverse populations. The SWAP was conceived because our patient advisory group for the review is concerned about the impact of co-existing osteoarthritis (OA) and pain on patient experience and success. Joint pain, OA, obesity, and type 2 diabetes (T2D) are common diseases that frequently coexist as Multiple Long Terms Conditions (MLTC), and many people taking part in LCD will live with these MLTCs. Importantly, research evidence that suggests a bidirectional relationship between weight and pain that may impact weight loss, and that systemic inflammation, found in obesity and diabetes, may be involved in the development and progression of OA pain.
This SWAP will recruit a subset of LCD participants who have OA pain to gather their views on the LCD, and to compare their outcomes to participants who do not have OA pain. Inflammatory biomarker data will be gathered using blood tests (Work Package A), and the experiences of the participants will be captured using interviews (Work Package B), to answer the following questions:
- What are the lived experiences of LCD programme participants who have co-existing OA
pain?
- What is the relationship between success of the LCD programme and inflammatory
biomarkers?
- Can the management of participants on the LCD programme with pre-existing OA pain, be
improved?This study presents a unique opportunity to understand the impact of OA pain on patient experience and inflammatory biomarkers, that will provide critical understanding as to how best to tailor programme support for this patient group.
REC name
HSC REC B
REC reference
22/NI/0141
Date of REC Opinion
22 Aug 2022
REC opinion
Favourable Opinion