The impact of exercise on the natural history of bicuspid aortic valve
Research type
Research Study
Full title
The impact of exercise on the natural history of bicuspid aortic valve
IRAS ID
307684
Contact name
Michael Papadakis
Contact email
Sponsor organisation
St George's University of London
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
The study has 2 parts:
1. Screening for the Bicuspid Aortic Valve (BAV) at cardiac screenings held by the charitable organisation Cardiac Risk in the Young (CRY) to assess the feasibility of screening a large group of volunteers for a bicuspid aortic valve.
2. Assessing the impact of exercise on progression of bicuspid aortic valve disease via an exercise questionnaire. The target group for this questionnaire will be individuals who are are patients of St George's Hospital NHS Trust, and those identified at CRY screening events.
Background:
The Bicuspid Aortic Valve (BAV) affects 1-2% of the population though quoted prevalence varies widely. It is recognised that problems with the valve may develop (stenosis and regurgitation) or the aorta (dilatation). The effect of exercise on the rate of development of valve disease in individuals with BAV is unknown.This study will attempt to provide further evidence for the true prevalence of the BAV by screening individuals who voluntarily attend a cardiac screening with a hand-held echocardiogram.
The study will also attempt to ascertain the effect of exercise on BAV progression by conducting a structured questionnaire pertaining to an individual's lifetime exercise. Individuals will then be classified as "athletes", "active" or "sedate". Clinical outcomes (including the need for an aortic valve replacement or aortic root replacement) and previous echocardiographic parameters in the 3 subgroups will be compared be to ascertain if there is a difference in progression of valve disease based on an individuals level of physical activity.
REC name
South Central - Berkshire B Research Ethics Committee
REC reference
22/SC/0358
Date of REC Opinion
22 Sep 2022
REC opinion
Further Information Favourable Opinion