The Igloo-CF Study
Research type
Research Study
Full title
The Impact of Gut dysbiosis on Lung inflammation : an ObservatiOnal study in cystic fibrosis (The Igloo Study)
IRAS ID
246456
Contact name
Daniel Peckham
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Cystic fibrosis (CF) is a condition which markedly impacts the lungs and gut. Lung inflammation, recurrent chest infections and declining lung function are cardinal features of CF. Therefore, focusing research on factors contributing to inflammation is imperative. A potential candidate may be the gut microbiome. While it is known the gut microbiome can impact gut inflammation and interact with the immune system, there is increasing evidence it could also alter inflammatory and immune responses in the lungs. Potentially substances, such as short chain fatty acids, produced by the microbiota are having a long-range influence on lung biology. Due to the condition itself, its treatments (including recurrent antibiotics) and altered diet in individuals with CF their gut microbiota may be altered. Therefore, understanding the interaction between the CF host and gut microbiota and the influence of dietary intervention on local, systemic and lung inflammation will provide new insights into how the gut microbiota contributes to disease progression and whether dietary modification could be exploited to alter CF pulmonary disease. This is a prospective observational study investigating the correlation between gut microbiome, abdominal symptoms, antibiotics and medications, diet, blood metabolites (metabolomics) and accelerated decline in lung function in patients with CF. It is to be conducted across three adult regional CF centres. Data will be collected from participants 18 years or above with CF at two time points six months apart. Data collected includes: stool samples, blood samples, dietary intake, abdominal symptoms and antibiotics taken.
REC name
London - Bromley Research Ethics Committee
REC reference
18/LO/2241
Date of REC Opinion
31 Jan 2019
REC opinion
Further Information Favourable Opinion