The HFpEF multisite pacing study
Research type
Research Study
Full title
Mechanistic Insights from Multisite Pacing in Patients with Heart Failure with Preserved Ejection Fraction
IRAS ID
332571
Contact name
Christopher Aldo Rinaldi
Contact email
Sponsor organisation
Guy's & St Thomas' Foundation NHS Trust - R&D
Duration of Study in the UK
2 years, 5 months, 31 days
Research summary
Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent cardiac condition, characterised by impaired diastolic function - it is due to a stiffening of the heart muscle and impaired relaxation resulting in decreased ability to pump blood around the body. When compared to other forms of heart failure, such as heart failure with reduced ejection fraction, which are due to impairment of the heart and result in a weak heart muscle, there is a relative paucity of specific treatments, leaving patients often debilitated by breathlessness and exercise intolerance. A recent new clinical trial has demonstrated multiple beneficial outcomes in HFpEF patients receiving personalised accelerated pacing from indwelling permanent pacemakers, including symptomatic improvement as well as objective reductions in heart enzyme levels and reduced burden of irregular heart rhythms.
We aim to determine the underlying mechanisms behind these documented effects of accelerated pacing in HFpEF patients. Specifically, we aim to investigate the acute intracardiac haemodynamic response to temporary specialised pacing in HFpEF patients who do not have indwelling permanent pacemakers. This will include the use of temporary pacing wires and pacing of the patients heart at different sites of the heart. We also aim to gain further mechanistic insight with additional haemodynamic, electrical and echocardiographic data collection during temporary pacing in this cohort. This will all provide valuable information towards new potential targets of therapy, in a cardiac condition hitherto lacking in meaningful therapeutic possibilities.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
24/WM/0092
Date of REC Opinion
14 Jun 2024
REC opinion
Further Information Favourable Opinion