The GUTPHOS Study
Research type
Research Study
Full title
Prospective, multicentre study to validate the GastroIntestinal Dysfunction Score (GIDS) and describe prevalence, outcomes, and management of phosphate disorders in intensive care patients
IRAS ID
333874
Contact name
Ramprasad Matsa
Contact email
Sponsor organisation
University Hospitals of North Midlands (UHNM)
Duration of Study in the UK
0 years, 6 months, 28 days
Research summary
The Study contains two parts:
Part A
Patients admitted to the Intensive Care Unit (ICU) develop multiple organ failure ( failure of vital organs such as lungs, brain, kidney, heart etc.). Prediction and/or anticipation of survival of such critically unwell patients is important to plan further treatment and to inform their family. Current scoring systems (tools to predict outcome called SOFA score etc.) utilise points based on failure of most vital organs but do not include gastrointestinal system (bowels) although gastrointestinal dysfunction (failure of the bowel function) affects patients in ICU.
Recently, Gastrointestinal Dysfunction Score (GIDS), that assess the failure of bowel function has been developed as a five-grade score (0-4). A small study performed to assess GIDS score, showed that it can independently predict 28- and 90-day survival. Therefore, a large study is needed to prospectively validate (prove that it works) GIDS score. The presence of a validated score would allow its use in further interventional studies currently hindered by the lack of a measurement tool. This part of the study aims to validate the GIDS score in a multicentre cohort (study done in more than one centre) of adult patients admitted to ICU.
Part B
ICU patients, have phosphate (a chemical that is essential to produce energy, muscle and nerve function, and bone growth) disturbances. Information regarding, how many ICU patients have such abnormality (prevalence) and how they are managed (treated) have not been studied prospectively (studies carried out from the present time into the future). Hence, there is also no clear answer on when to treat such phosphate abnormalities.
In this part of the study, we aim to identify the prevalence, management practices, and outcomes of phosphate abnormalities during the first week of ICU admission. The results of this study could provide clinical guidance in Phosphate management.
REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
24/NE/0133
Date of REC Opinion
22 Jul 2024
REC opinion
Further Information Favourable Opinion